Sunifiram (DM-235) is a synthetic piperazine-derived ampakine engineered as a potent positive allosteric modulator (PAM) of AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptors. By enhancing AMPA-mediated excitatory post-synaptic currents, Sunifiram facilitates hippocampal Long-Term Potentiation (LTP), stimulates presynaptic acetylcholine (ACh) release in cortical tissues, and upregulates CaMKII phosphorylation.
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| Quantity | Discounted Price |
|---|---|
| 4 - 6 | $61.44 |
| 7 - 9 | $60.16 |
| 10 + | $58.88 |
Sunifiram (known chemically as DM-235 or 1-(4-benzoylpiperazin-1-yl)propan-1-one) is a novel synthetic piperazine derivative belonging to the ampakine class of cognitive research compounds. Originally developed as a structurally optimized derivative of piracetam, Sunifiram departs from the classic pyrrolidone ring structure, utilizing a piperazine core that yields significantly higher potency at AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptors.
Operating as a positive allosteric modulator (PAM), Sunifiram slows AMPA receptor desensitization during active glutamatergic transmission. This enhances post-synaptic sodium and calcium (Ca2+) ion influx, facilitating hippocampal Long-Term Potentiation (LTP) and increasing cortical acetylcholine (ACh) release.
Batch-verified for high analytical purity at Modern Aminos, Sunifiram is offered in a 50MG/ML liquid solution packaged in a 30ML amber glass bottle with a 1mL precision dropper. Laboratories evaluating glutamatergic synaptic plasticity, memory consolidation networks, and presynaptic neurotransmitter release utilize Sunifiram alongside complementary neuro-active reference standards available on the site, such as Alpha GPC, Bromantane, 9-Me-BC, and NSI-189 Phosphate.
| Compound Name | Sunifiram (DM-235) |
|---|---|
| Quantity / Formats Offered | 50MG/ML Liquid Solution (30ML Amber Glass Bottle with 1mL Dropper) |
| Synonyms / Alt Names | DM-235, Sunifiram, Piperazine Ampakine DM-235 |
| CAS Number | 314728-85-3 |
| Chemical Formula | C16H22N2O2 |
| Molecular Weight | 274.36 g/mol |
| IUPAC Name | 1-(4-benzoylpiperazin-1-yl)propan-1-one |
| InChIKey | Protected Small Molecule Structure |
| SMILES Code | CCC(=O)N1CCN(CC1)C(=O)C2=CC=CC=C2 |
The biochemical pathways and cellular targets of Sunifiram in laboratory research include:
When evaluating research efficacy and published scientific literature for Sunifiram (DM-235):
To evaluate glutamatergic signaling, cholinergic release, and synaptic modulation, researchers compare Sunifiram against alternative reference standards available at Modern Aminos:
| Compound / Reference | Chemical Class & Structure | Core Mechanism of Action | Research Focus & Profile |
|---|---|---|---|
| Sunifiram (DM-235) | Piperazine-Derived Ampakine Modulator | Positive allosteric modulation of AMPA receptors, facilitating LTP and cortical acetylcholine release | Focuses on AMPA receptor channel kinetics, CaMKII activation, LTP induction, and presynaptic ACh signaling |
| Alpha GPC | L-α-Glycerophosphocholine Phospholipid | Provides bioavailable free choline for direct acetylcholine synthesis and neuronal membrane phospholipid repair | Focuses on baseline acetylcholine substrate availability, membrane fluidity, and systemic cholinergic precursor loading |
| Bromantane | Synthetic Adamantane Actoprotector | Upregulates Tyrosine Hydroxylase (TH) gene expression to increase de novo dopamine synthesis | Focuses on non-depleting dopaminergic biosynthesis, actoprotective physical endurance, and non-sedating anxiolysis |
| 9-Me-BC | Methylated β-Carboline Derivative | Induces Tyrosine Hydroxylase gene expression, drives dopaminergic neurite outgrowth, and supports Complex I | Focuses on dopaminergic neuronal structural restoration and mitochondrial respiratory chain support |
Yes, Modern Aminos is a highly trusted vendor for high-purity research chemicals and novel neuro-active reference standards. Every batch of Sunifiram undergoes strict third-party analytical testing (including HPLC and Mass Spectrometry) to verify minimum 98%+ chemical purity, exact 50MG/ML concentration, and complete absence of heavy metals or synthesis impurities.
Sunifiram (DM-235) is a synthetic piperazine derivative and ampakine compound. It is classified chemically as a positive allosteric modulator (PAM) of AMPA glutamatergic receptors.
Sunifiram binds allosterically to AMPA receptor complexes, slowing their rate of desensitization when glutamate is present. This prolongs excitatory post-synaptic currents and enhances calcium influx into dendritic spines.
In preclinical neural tissue assays, Sunifiram stimulates impulse-dependent acetylcholine release in the cerebral cortex, bridging glutamatergic AMPA receptor modulation with downstream cholinergic network activity.
Modern Aminos provides Sunifiram in a pre-mixed 50MG/ML liquid solution packaged in a 30ML amber glass bottle with a calibrated 1mL precision dropper for exact volumetric sampling.
While structurally related to Unifiram, Sunifiram replaces the pyrrolizridine core with a piperazine ring, displaying enhanced potency in AMPA receptor modulation and Long-Term Potentiation (LTP) facilitation compared to traditional racetams.
Modern Aminos uses High-Performance Liquid Chromatography (HPLC) to confirm purity profiles exceeding 98% and Mass Spectrometry (MS) to verify exact molecular weight (274.36 g/mol) prior to batch release.
Liquid Sunifiram bottles should be stored tightly sealed in a cool, dry environment (15°C to 25°C) protected from direct sunlight and heat. Amber glass packaging protects the solution from photochemical degradation over extended shelf lives.
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