MK-2866 (Ostarine / Enobosarm / GTx-024) is an investigational nonsteroidal Selective Androgen Receptor Modulator (SARM) belonging to the aryl-propionamide chemical class (CAS 841205-47-8). It binds human androgen receptors with high sub-nanomolar affinity (Ki = 3.8 nM) to stimulate tissue-selective anabolic gene expression (MyoD, myogenin, MyH) without undergoing enzymatic conversion to DHT via 5α-reductase or estrogen via aromatase.
Price range: $54.00 through $94.00
| Quantity | Discounted Price |
|---|---|
| 4 - 6 | $51.84 |
| 7 - 9 | $50.76 |
| 10 + | $49.68 |
MK-2866 (known chemically as Ostarine, Enobosarm, GTx-024, or S-22) is an investigational nonsteroidal Selective Androgen Receptor Modulator (SARM) belonging to the aryl-propionamide chemical class. Originally developed by GTx, Inc. to combat sarcopenia, MK-2866 binds the ligand-binding domain of androgen receptors with high affinity (Ki = 3.8 nM). Because its nonsteroidal backbone escapes enzymatic conversion by 5α-reductase into dihydrotestosterone (DHT) and aromatase into estrogen, MK-2866 functions as a foundational baseline reference for tissue-selective anabolic signaling.
Batch-verified for high analytical purity at Modern Aminos, MK-2866 is supplied in three versatile laboratory formats:
Researchers evaluating myocyte differentiation, receptor binding kinetics, and nitrogen retention dynamics utilize MK-2866 alongside related nonsteroidal SARMs on the site, such as LGD-4033, RAD-140, S4, and RAD-150.
| Compound Name | MK-2866 (Ostarine) |
|---|---|
| Quantity / Formats Offered | 30ML Liquid Dropper | 60-Unit Dry-Fill Capsules | 10ML MCT Oil Vial |
| Synonyms / Alt Names | Ostarine, Enobosarm, GTx-024, S-22, MK2866 |
| CAS Number | 841205-47-8 |
| Chemical Formula | C19H14F3N3O3 |
| Molecular Weight | 389.33 g/mol |
| IUPAC Name | (2S)-3-(4-cyanophenoxy)-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methylpropanamide |
| InChIKey | JNGVJMBLXIUVRD-SFHVURJKSA-N |
| SMILES Code | CC(C(=O)NC1=CC(=C(C=C1)C#N)C(F)(F)F)(COC2=CC=C(C=C2)C#N)O |
The biochemical pathways and cellular targets of MK-2866 in laboratory research include:
When evaluating research efficacy and published scientific literature for MK-2866 (Ostarine):
To evaluate receptor binding kinetics, tissue selectivity, and anabolic signaling pathways, researchers compare MK-2866 against alternative nonsteroidal SARMs available at Modern Aminos:
| Compound / Reference | Chemical Class | Core Mechanism of Action | Research Focus & Profile |
|---|---|---|---|
| MK-2866 (Ostarine) | Aryl-Propionamide Nonsteroidal SARM | Selective AR agonism (Ki = 3.8 nM) driving MyoD and myogenin myogenic transcription | Gold-standard baseline reference for tissue-selective anabolic signaling, myocyte differentiation, and muscle wasting research |
| LGD-4033 (Ligandrol) | Pyrrolidinyl-Benzonitrile SARM | Binds the androgen receptor with sub-nanomolar affinity (Ki = 1 nM) | Evaluates high-potency anabolic muscle building and bone mineral density responses in cell models |
| RAD-140 (Testolone) | Substituted Benzimidazole SARM | Tissue-selective AR agonism featuring neuroprotective crosstalk in neuronal cell cultures | Focuses on heavy anabolic signaling in muscle and androgenic neuroprotective pathways in central tissue models |
| S4 (Andarine) | Aryl-Propionamide First-Generation SARM | Partial AR agonist (Ki = 4 nM) targeting skeletal muscle and prostate tissue selectivity | Pioneer reference compound evaluated for partial agonism, lean mass retention, and vascular lipid clearance |
Yes, Modern Aminos is a trusted supplier of high-purity research chemicals and nonsteroidal SARM reference standards. Every batch of MK-2866 undergoes strict third-party analytical testing (including HPLC and Mass Spectrometry) to verify minimum 98%+ purity, correct molecular weight (389.33 g/mol), and complete absence of unreacted synthetic precursors or heavy metals.
MK-2866 is an aryl-propionamide nonsteroidal selective androgen receptor modulator (SARM). It targets the ligand-binding domain of human androgen receptors with high affinity (Ki = 3.8 nM), selective for muscle and bone tissue models.
In C2C12 and L6 skeletal muscle cell lines, MK-2866 activates ERK1/2 kinase signaling through androgen receptor binding. This upregulates the myogenic transcription factors MyoD, myogenin, and myosin heavy chain (MyH), driving muscle cell proliferation and differentiation.
No. MK-2866 possesses a nonsteroidal chemical backbone that cannot be converted into dihydrotestosterone (DHT) by 5α-reductase, nor into estrogen by aromatase. This isolates its experimental activity strictly to the androgen receptor without secondary steroidal metabolite formation.
Modern Aminos provides MK-2866 in three standardized formats: a 30ML aqueous liquid solution with 1mL dropper, 60-unit dry-fill solid oral capsules, and a 10ML MCT-based oil solution vial. All three formats deliver consistent active material purity for in vitro screening protocols.
Both compounds are potent nonsteroidal SARMs. LGD-4033 belongs to the pyrrolidinyl-benzonitrile class and exhibits higher binding affinity (Ki = 1 nM), whereas MK-2866 (Ki = 3.8 nM) belongs to the aryl-propionamide class and represents the most widely cited baseline reference in muscle wasting literature.
Due to its extensive preclinical and Phase I/II clinical trial documentation, MK-2866 serves as the primary benchmark compound for validating androgen receptor assay selectivity, competitive ligand displacement, and anabolic vs. androgenic gene expression profiling.
Liquid dropper bottles, capsule containers, and MCT solution vials should be stored tightly sealed in a cool, dry environment (15°C to 25°C) away from direct light, heat, and moisture. Liquid formulations do not require an external reconstitution solution prior to laboratory testing.
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