L-THP (Levo-tetrahydropalmatine / (-)-THP / Rotundine) is a purified, stereoselective tetrahydroprotoberberine isoquinoline alkaloid isolated from Stephania and Corydalis species. Engineered as a multi-target central nervous system modulator, L-THP acts as a high-affinity antagonist of dopamine D1, D2, and D3 receptors while agonizing 5-HT1A serotonin receptors and facilitating GABAergic inhibitory signaling.
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| Quantity | Discounted Price |
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| 10 + | $35.88 |
L-THP (known chemically as Levo-tetrahydropalmatine, (-)-tetrahydropalmatine, or Rotundine) is the levorotatory enantiomer of the active tetrahydroprotoberberine alkaloid found naturally in botanical genera such as Stephania and Corydalis. Structurally classified as an isoquinoline derivative ((13aR)-2,3,9,10-tetramethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline), L-THP exhibits stereospecific neuropharmacological actions distinct from its dextrorotatory counterpart.
Operating across multiple monoaminergic and amino acid neurotransmitter systems, L-THP functions primarily as a potent competitive antagonist at dopamine D1, D2, and D3 receptors. In addition to attenuating hyper-dopaminergic signaling, L-THP interacts with serotonin 5-HT1A receptors, promotes gamma-aminobutyric acid (GABA) receptor activity, and inhibits voltage-dependent L-type calcium channels, providing a versatile model for investigating central sedative, analgesic, and neuroprotective pathways.
Batch-verified for high analytical purity at Modern Aminos, L-THP is offered in a pre-measured 50MG dry-fill solid capsule format (60 units per bottle). Researchers evaluating dopaminergic reward pathways, central sedation mechanics, and cellular stress mitigation utilize L-THP alongside complementary neurochemical reference standards available on the site, such as Bromantane, Nooglutyl, 9-Me-BC, and NSI-189 Phosphate.
| Compound Name | L-THP (Levo-tetrahydropalmatine) |
|---|---|
| Quantity / Formats Offered | 50MG Dry-Fill Capsules (60 Units per Bottle) |
| Chemical Structure | Tetrahydroprotoberberine Isoquinoline Alkaloid |
| Synonyms / Alt Names | (-)-Tetrahydropalmatine, L-Tetrahydropalmatine, Rotundine, l-THP, Gindarin |
| CAS Number | 3520-14-7 (L-Enantiomer) | 483-14-7 (Racemic Base) |
| Chemical Formula | C21H25NO4 |
| Molecular Weight | 355.43 g/mol |
| IUPAC Name | (13aR)-2,3,9,10-tetramethoxy-6,8,13,13a-tetrahydro-5H-isoquinolino[2,1-b]isoquinoline |
| InChIKey | InChIKey=AXPZWNYIKGZNFT-SECPINFHSA-N |
| SMILES Code | COC1=C(C2=C(C=C1)C[C@@H]3C4=CC(=C(C=C4CCN3C2)OC)OC)OC |
The biochemical pathways and cellular targets of L-THP (Levo-tetrahydropalmatine) in laboratory research include:
When evaluating research efficacy and published scientific literature for L-THP (Levo-tetrahydropalmatine):
To evaluate receptor binding profiles, stereospecificity, and monoaminergic kinetics, researchers compare L-THP against alternative reference standards available at Modern Aminos:
In cellular neuropharmacology and receptor screening, enantiomeric purity and mechanism direction define experimental targets:
| Compound / Reference | Chemical Structure & Class | Core Mechanism of Action | Research Focus & Profile |
|---|---|---|---|
| L-THP (Levo-THP) | Purified (13aR) Tetrahydroprotoberberine Alkaloid | Competitive D1/D2/D3 dopamine antagonist; 5-HT1A agonist; GABA facilitator | Focuses on dopaminergic dampening, mesolimbic signaling inhibition, sedation pathway, and calcium channel modulation |
| Racemic dl-THP | 50:50 Enantiomeric Alkaloid Mixture | Combined D2 receptor blockade (L-isomer) and presynaptic monoamine depletion (D-isomer) | Focuses on unpurified total alkaloid action, general central depression, and non-enantioselective screening |
| Bromantane | Synthetic Adamantane Actoprotector | Upregulates Tyrosine Hydroxylase (TH) to stimulate de novo dopamine synthesis while modulating GABA | Focuses on dopaminergic signaling modulation, sustained cellular bioenergetics, metabolic resilience under challenge, and the attenuation of excitatory signaling cascades. |
| Nooglutyl | N-Acyl L-Glutamic Acid Derivative | Positively modulates post-synaptic AMPA and NMDA glutamatergic receptor complexes | Focuses on excitatory glutamatergic synaptic plasticity, hippocampal LTP facilitation, and anti-hypoxic resilience |
Yes, Modern Aminos is a highly trusted vendor for high-purity research chemicals and reference alkaloids. Every batch undergoes strict third-party analytical testing (including HPLC and Mass Spectrometry) to verify minimum 98%+ chemical purity, enantiomeric levo-purity, correct molecular weight (355.43 g/mol), and complete absence of heavy metals, residual solvents, or synthesis contaminants.
L-THP is the purified levorotatory (S)-enantiomer of tetrahydropalmatine. It is classified chemically as a tetrahydroprotoberberine isoquinoline alkaloid designed for receptor binding and neurochemical signaling research.
L-THP acts as a competitive antagonist at dopamine D1, D2, and D3 receptors in the central nervous system. By blocking dopamine binding, it attenuates post-synaptic dopaminergic signal transduction in mesolimbic pathways.
L-THP is the isolated levo-isomer responsible for specific D1/D2 receptor antagonism and sedative effects. Racemic dl-THP contains both the levo- and dextro-isomers; the dextro-isomer possesses distinct monoamine-depleting properties that alter receptor specificity.
L-THP acts as a partial agonist at 5-HT1A receptors and enhances GABAA receptor-mediated chloride currents, facilitating inhibitory neurotransmission and reducing neuronal excitability in cell culture models.
Bromantane upregulates Tyrosine Hydroxylase to drive endogenous dopamine synthesis and support sustained cellular bioenergetics under metabolic demand. In contrast, L-THP acts as a dopamine receptor antagonist, dampening dopaminergic activity to evaluate the attenuation of excitatory signaling and study inhibitory neurotransmission pathways.
Modern Aminos utilizes High-Performance Liquid Chromatography (HPLC) with chiral columns to confirm >98% enantiomeric purity and Mass Spectrometry (MS) to verify exact molecular weight (355.43 g/mol) and active compound mass prior to batch release.
L-THP capsule bottles should be stored tightly sealed in a cool, dry environment (15°C to 25°C) protected from direct sunlight, light exposure, and atmospheric moisture. Under controlled room temperature conditions, L-THP maintains complete solid-state chemical stability throughout its designated shelf life.
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