GB-115 (N-(6-phenylhexanoyl)-glycyl-L-tryptophan amide) is a synthetic retrodipeptide derivative of cholecystokinin tetrapeptide (CCK-4) engineered for central neuropeptide receptor research. Operating as a selective cholecystokinin (CCK-1 / CCK-2) receptor antagonist, GB-115 attenuates stress-induced emotional cascades and hyper-reactivity in behavioral assays without inducing sedation or motor impairment.
$54.00
In stock
| Quantity | Discounted Price |
|---|---|
| 4 - 6 | $51.84 |
| 7 - 9 | $50.76 |
| 10 + | $49.68 |
GB-115 (known chemically as N-(6-phenylhexanoyl)-glycyl-L-tryptophan amide or Ranquilon) is a novel synthetic dipeptide derived from the topochemical structure of cholecystokinin tetrapeptide (CCK-4). Originally designed at the V.V. Zakusov Research Institute of Pharmacology through peptide-based drug design, GB-115 functions as an endogenous-like retrodipeptide that selectively antagonizes central cholecystokinin (CCK-1 and CCK-2) receptors.
Batch-verified for high analytical purity at Modern Aminos, GB-115 is supplied in a pre-measured 2.5MG dry-fill oral capsule format (60 units per bottle). Researchers studying neuropeptide signal transduction, emotional stress buffering, and non-GABAergic anxiolysis utilize GB-115 alongside complementary central nervous system modulators available on the site, such as Selank, Noopept, and Phenibut HCL.
| Compound Name | GB-115 |
|---|---|
| Quantity / Formats Offered | 2.5MG Dry-Fill Capsules (60 Units per Bottle) |
| Synonyms / Alt Names | Ranquilon, N-(6-phenylhexanoyl)glycyl-L-tryptophan amide, CCK-4 Retrodipeptide Analog |
| CAS Number | 678996-63-9 |
| Chemical Formula | C25H30N4O3 |
| Molecular Weight | 434.54 g/mol |
| IUPAC Name | N-[2-[[(1S)-1-carbamoyl-2-(1H-indol-3-yl)ethyl]amino]-2-oxoethyl]-6-phenylhexanamide |
| InChIKey | ZBIQNIJICMOVKN-QFIPXVFZSA-N |
| SMILES Code | O=C(CCCCCC1=CC=CC=C1)NCC(=O)N[C@@H](CC2=CNC3=CC=CC=C32)C(N)=O |
The biochemical pathways and cellular targets:
When evaluating research efficacy and published scientific literature:
To evaluate neuropeptide targets, stress buffering pathways, and cognitive profiles, researchers compare GB-115 against alternative reference compounds available at Modern Aminos:
| Compound / Reference | Primary Receptor Class | Core Mechanism of Action | Research Focus & Profile |
|---|---|---|---|
| GB-115 | Cholecystokinin (CCK-1 / CCK-2) Receptor Antagonist | Blocks central CCK receptors to dampen stress-induced emotional cascades without engaging GABA-A sites | Focuses on neuropeptide-mediated anxiolysis, avoidance-behavior dampening, and stress resistance without sedation |
| Selank | Synthetic Tuftsin-Derived Heptapeptide | Modulates central enkephalin stability, BDNF expression, and GABAergic neurotransmission | Focuses on neurotrophic factor stimulation, immune-system modulation, and steady-state anxiety reduction |
| Noopept | Cycloprolylglycine Dipeptide Mimetic | Sensitizes central AMPA/NMDA receptors and upregulates hippocampal BDNF and NGF expression | Focuses on cognitive enhancement, memory consolidation, and long-term neuroprotection rather than direct CCK antagonism |
| Phenibut HCL | β-Phenyl-GABA Derivative | Acts as a direct agonist at GABA-B receptors and blocks voltage-gated calcium channels (α2δ subunit) | Focuses on heavy GABAergic sedation, muscle relaxation, and acute central nervous system depression |
Yes, Modern Aminos is a highly trusted vendor for high-purity research chemicals and reference peptides. Every batch undergoes strict third-party analytical testing (including HPLC and Mass Spectrometry) to verify minimum 98%+ purity, correct molecular mass (434.54 g/mol), and complete absence of unreacted synthetic precursors or heavy metals.
GB-115 is an N-acylated retrodipeptide derived from cholecystokinin tetrapeptide (CCK-4). Its chemical structure consists of N-(6-phenylhexanoyl)-glycyl-L-tryptophan amide. It functions as a selective competitive antagonist at central CCK-1 and CCK-2 receptors.
Cholecystokinin is an endogenous neuropeptide that triggers panic-like behaviors and anxiety cascades when binding CCK receptors in the amygdala and hypothalamus. By competitively blocking CCK-1 and CCK-2 receptors, it prevents hyper-activation of these emotional stress centers.
Unlike classic GABA-A receptor agonists or benzodiazepines, it operates entirely through the neuropeptidergic cholecystokinin pathway. Because it does not enhance GABA-chloride channel influx, it does not induce motor impairment, muscle relaxation, memory disruption, or sedation.
Modern Aminos supplies pre-measured 2.5MG dry-fill solid capsules (60 units per bottle). This format ensures precise unit-mass accuracy for solid-state laboratory assays, preventing weighing errors and eliminating solution handling variance.
While both are synthetic peptide-derived anxiolytic agents, Selank is a heptapeptide derived from tuftsin that stabilizes endogenous enkephalins and increases BDNF. GB-115 is a retrodipeptide that specifically targets cholecystokinin (CCK) receptor blockade.
GB-115 was designed and synthesized at the V.V. Zakusov Research Institute of Pharmacology as part of an advanced dipeptide drug discovery program—the same institution responsible for developing Noopept, Dilept, and related neuropeptide mimetics.
Containers holding dry-fill GB-115 capsules should be kept tightly sealed in a cool, dry environment (15°C to 25°C) away from direct sunlight, excess heat, and humidity. Stored under controlled room conditions, GB-115 maintains complete chemical stability throughout its designated shelf life.
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