ATX-304 (O-304) is a potent, orally active pan-agonist of AMP-activated protein kinase (AMPK) engineered for cellular energy homeostasis, metabolic regulation, and mitochondrial biogenesis research. By allosterically activating AMPK complexes, ATX-304 promotes GLUT4 glucose transporter translocation, accelerates fatty acid beta-oxidation, and reduces hepatic lipid accumulation in cell culture models.
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ATX-304 (known chemically as O-304, O 304, or ATX 304) is a novel, small-molecule pan-agonist that directly targets AMP-activated protein kinase (AMPK). Engineered to overcome the limited stability and high micromolar requirement of first-generation nucleoside analogs, ATX-304 allosterically activates AMPK across heterotrimeric isoform complexes with low nanomolar potency.
Batch-verified for high analytical purity at Modern Aminos, ATX-304 is supplied in a pre-measured 100MG dry-fill oral capsule format (60 units per bottle). Laboratories evaluating cellular energy sensing, substrate switching, and glucose handling utilize ATX-304 alongside complementary metabolic reference standards available on the site, such as AICAR, SLU-PP-332, GW-501516, and DADA.
| Compound Name | ATX-304 (O-304) |
|---|---|
| Quantity / Formats Offered | 100MG Dry-Fill Capsules (60 Units per Bottle) |
| Synonyms / Alt Names | O-304, O 304, ATX 304, Allosteric AMPK Activator 304 |
| CAS Number | 1632128-44-3 |
| Chemical Formula | C21H18ClN3O2S |
| Molecular Weight | 411.91 g/mol |
| IUPAC Name | 3-(4-chlorophenyl)-N-[4-(4-methoxyphenyl)-1,3-thiazol-2-yl]propanamide |
| InChIKey | Protected Small Molecule Matrix |
| SMILES Code | COC1=CC=C(C=C1)C2=CSC(=N2)NC(=O)CCC3=CC=C(C=C3)Cl |
The biochemical pathways and cellular targets of ATX-304 in laboratory research include:
When evaluating research efficacy and published scientific literature for ATX-304 (O-304):
To evaluate energy-sensing targets, mitochondrial biogenesis, and metabolic signaling pathways, researchers compare ATX-304 against alternative reference compounds available at Modern Aminos:
| Compound / Reference | Primary Target Class | Core Mechanism of Action | Research Focus & Profile |
|---|---|---|---|
| ATX-304 (O-304) | Direct Allosteric Pan-AMPK Activator | Binds the AMPK α/β subunit interface to prevent Thr-172 dephosphorylation and stimulate GLUT4 glucose translocation | Focuses on allosteric AMPK kinetics, non-insulin glucose uptake, lipid oxidation, and anti-gluconeogenic pathway research |
| AICAR | AMP-Mimetic Nucleoside Agonist | Converted intracellularly into ZMP to mimic AMP binding on the AMPK $\gamma$ subunit | Pioneer reference compound evaluated for AMP-like metabolic activation, requiring higher micromolar concentrations in vitro |
| SLU-PP-332 | Pan-ERR Nuclear Receptor Agonist | Directly activates Estrogen-Related Receptors (ERRα/β/γ) to stimulate PGC-1α and OXPHOS complexes | Focuses on nuclear receptor-driven exercise mimetics, oxidative muscle fiber switching, and respiratory chain biogenesis |
| GW-501516 (Cardarine) | PPARδ Selective Agonist | Recruits PGC-1α to upregulate skeletal muscle fatty acid beta-oxidation and PDK4 expression | Focuses on PPARδ nuclear receptor signaling, fatty acid transport (FAT/CD36), and glucose sparing in myocytes |
Yes, Modern Aminos is a highly trusted vendor for high-purity research chemicals and novel metabolic reference standards. Every batch of ATX-304 undergoes strict third-party analytical testing (including HPLC and Mass Spectrometry) to verify minimum 98%+ purity, correct molecular weight (411.91 g/mol), and complete absence of unreacted synthetic precursors or heavy metals.
ATX-304 (O-304) is a synthetic, small-molecule allosteric activator of AMP-activated protein kinase (AMPK). It functions as a pan-AMPK agonist, activating multiple heterotrimeric isoform complexes containing α1 or α2 catalytic subunits.
AICAR must be phosphorylated intracellularly into ZMP to mimic AMP binding at the regulatory γ subunit. ATX-304 binds directly to an allosteric site between the α and β subunits, locking the enzyme in an active conformation and protecting Thr-172 from dephosphorylation without requiring metabolic conversion.
In cell culture models, ATX-304 promotes non-insulin-dependent glucose uptake by stimulating GLUT4 translocation. Simultaneously, it phosphorylates and inactivates Acetyl-CoA Carboxylase (ACC), shifting lipid metabolism toward fatty acid oxidation and inhibiting lipogenesis.
Modern Aminos provides ATX-304 in pre-measured 100MG dry-fill solid capsules (60 units per bottle). This format ensures exact unit-mass accuracy for solid-state laboratory assays, preventing weighing errors and eliminating solution handling variance.
GW-501516 is a nuclear receptor agonist that targets PPARδ to upregulate fatty acid oxidation genes. ATX-304 targets the cytosolic master metabolic enzyme AMPK directly, regulating short-term enzymatic activity (ACC inhibition, GLUT4 movement) alongside long-term PGC-1α gene transcription.
ATX-304 dry-fill capsule contents are readily soluble in lipophilic organic solvents such as dimethyl sulfoxide (DMSO) and ethanol.
Bottles containing dry-fill ATX-304 capsules should be stored tightly sealed in a cool, dry environment (15°C to 25°C) away from direct sunlight, excess heat, and moisture. Stored under controlled room conditions, ATX-304 capsules maintain complete chemical stability throughout their designated shelf life.
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