5% RU-58841 Topical Serum (PSK-3841) is a synthetic non-steroidal antiandrogen (NSAA) engineered as a high-affinity competitive antagonist of the androgen receptor (AR). By occupying the ligand-binding domain of cellular androgen receptors, RU-58841 blocks endogenous dihydrotestosterone (DHT) and testosterone binding, preventing receptor nuclear translocation and downstream gene transcription in dermal papilla and follicular cell lines.
$48.00
In stock
| Quantity | Discounted Price |
|---|---|
| 4 - 6 | $46.08 |
| 7 - 9 | $45.12 |
| 10 + | $44.16 |
5% RU-58841 Topical Serum (known chemically as PSK-3841, HMR-3841, or 4-[3-(4-hydroxybutyl)-4,4-dimethyl-2,5-dioxoimidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile) is a pioneer non-steroidal antiandrogen (NSAA). Developed specifically as a localized, high-affinity antagonist of the androgen receptor (AR), RU-58841 exhibits high binding selectivity for AR complexes over other steroid hormone receptors (such as glucocorticoid, estrogen, or progesterone receptors).
Unlike 5α-reductase inhibitors that block the enzymatic conversion of testosterone to dihydrotestosterone (DHT), RU-58841 acts directly at the receptor level. Occupying the ligand-binding domain (LBD) of target cell androgen receptors prevents both DHT and testosterone from forming active transcription complexes, insulating cellular machinery from androgenic signaling without altering systemic 5α-reductase enzyme levels.
Batch-verified for high analytical purity at Modern Aminos, 5% RU-58841 Topical Serum is offered as a standardized reference material for cell culture and biochemical research. Researchers evaluating dermal papilla cell proliferation, sebocyte lipogenesis, and androgen receptor dimerization kinetics utilize RU-58841 alongside complementary tissue-regulatory reference standards available on the site, such as Pyrilutamide (KX-826), CB-03-01 (Clascoterone), GHK-Cu, and BPC-157.
| Compound Name | RU-58841 (PSK-3841 / HMR-3841) |
|---|---|
| Quantity / Formats Offered | High-Purity Dry Reference Powder / Solid Unit Material |
| Chemical Structure | Fluorinated Imidazolidinedione Non-Steroidal Antiandrogen |
| Synonyms / Alt Names | RU58841, PSK-3841, HMR-3841, RU-58841 Base, NSAA RU-58841 |
| CAS Number | 154992-24-2 |
| Chemical Formula | C17H18F3N3O3 |
| Molecular Weight | 369.34 g/mol |
| IUPAC Name | 4-[3-(4-hydroxybutyl)-4,4-dimethyl-2,5-dioxoimidazolidin-1-yl]-2-(trifluoromethyl)benzonitrile |
| InChIKey | InChIKey=InChIKey=OQVIYIHKXNWXKS-UHFFFAOYSA-N |
| SMILES Code | CC1(C(=O)N(C(=O)N1CCCCO)C2=CC(=C(C=C2)C#N)C(F)(F)F)C |
The biochemical pathways and cellular targets of RU-58841 in laboratory research include:
When evaluating research efficacy and published scientific literature for 5% RU-58841 Topical Serum (PSK-3841):
To evaluate receptor binding affinity, target specificity, and signaling mechanics, researchers compare 5% RU-58841 Topical Serum against alternative reference standards available at Modern Aminos:
In androgen signaling and cellular pathology research, the site of pathway intervention determines experimental parameters:
| Compound / Reference | Chemical Structure & Class | Core Mechanism of Action | Research Focus & Profile |
|---|---|---|---|
| RU-58841 | Fluorinated Imidazolidinedione NSAA | Competitive AR antagonist; occupies ligand-binding domain to block DHT and testosterone binding | Focuses on androgen receptor isolation, dermal papilla cell protection, AR dimerization inhibition, and NSAA kinetics |
| Pyrilutamide (KX-826) | Second-Generation Non-Steroidal Antiandrogen | High-affinity competitive AR antagonist engineered for elevated local binding potency and rapid metabolic clearance | Focuses on next-generation AR competitive kinetics, local receptor occupancy, and sebocyte pathway modulation |
| CB-03-01 (Clascoterone) | Steroidal Antiandrogen (Cortexolone Derivative) | Competes with DHT for androgen receptor binding at the local tissue level, metabolizing into inactive cortexolone | Focuses on steroidal AR competition, local tissue antiandrogenic action, and sebaceous gland signaling assays |
| GHK-Cu | Copper-Chelated Tripeptide (Gly-His-Lys) | Upregulates collagen, elastin, and extracellular matrix (ECM) gene networks while stimulating SOD1 antioxidant activity | Focuses on tissue remodeling, extracellular matrix synthesis, angiogenesis, and anti-inflammatory signaling |
Yes, Modern Aminos is a highly trusted vendor for high-purity research chemicals and reference compounds. Every batch of RU-58841 undergoes strict third-party analytical testing (including HPLC and Mass Spectrometry) to verify minimum 98%+ chemical purity, correct molecular weight (369.34 g/mol), exact antiandrogenic structure fidelity, and complete absence of heavy metals or synthesis impurities.
RU-58841 (PSK-3841) is a synthetic fluorinated imidazolidinedione derivative. It is classified chemically as a non-steroidal antiandrogen (NSAA) and competitive androgen receptor antagonist.
RU-58841 binds competitively to the ligand-binding domain (LBD) of human androgen receptors with nanomolar affinity (Ki ≈ 1.1 nM). By occupying the receptor site, it prevents endogenous DHT and testosterone from binding and initiating receptor dimerization.
Finasteride inhibits the 5α-reductase enzyme to block the conversion of testosterone into DHT. RU-58841 acts directly at the androgen receptor level, blocking both DHT and testosterone from binding to the receptor without altering enzyme activity or hormone synthesis.
In dermal papilla cell cultures, RU-58841 attenuates DHT-induced apoptosis and growth arrest, allowing researchers to study androgen-independent cellular proliferation, protein synthesis, and hair follicle growth dynamics in vitro.
RU-58841, Pyrilutamide (KX-826), and CB-03-01 all function as competitive androgen receptor antagonists. RU-58841 is the classic non-steroidal NSAA reference standard, Pyrilutamide is a high-affinity second-generation NSAA, and CB-03-01 is a steroidal cortexolone-derived antagonist.
Modern Aminos utilizes High-Performance Liquid Chromatography (HPLC) to confirm active chemical purity exceeding 98% and Mass Spectrometry (MS) to verify exact molecular weight (369.34 g/mol) and structural identity prior to batch release.
Reference material should be stored tightly sealed in a cool, dry environment (15°C to 25°C) or refrigerated for long-term preservation. Protect from direct heat, light exposure, and atmospheric moisture to maintain solid-state chemical stability.
Disclaimer: All compounds and research materials provided by Modern Aminos are strictly for laboratory and research professional use only. They are not approved for human or animal use nor consumption by the Food and Drug Administration (FDA). These products should not be used for any form of in vivo experimentation or for any other non-laboratory purpose. Any violation or indication of human or animal use will result in immediate removal from being able to purchase products in the future. By purchasing these products, you acknowledge that they will be used exclusively within a controlled and qualified research environment.
The products offered by Modern Aminos are intended strictly for laboratory research purposes only and are sold exclusively to qualified professionals, institutions, and entities. These products are not for human consumption, veterinary use, or any other application involving living organisms, including but not limited to diagnostic, therapeutic, or recreational purposes.
By purchasing this product, you confirm that:
Modern Aminos does not claim that this product is approved by the U.S. Food and Drug Administration (FDA) for any purpose. The statements regarding this product have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.
The buyer assumes full responsibility for ensuring the safe handling, storage, and use of this product. Modern Aminos is not liable for any damages, direct or indirect, resulting from improper handling, storage, or unauthorized use of this product. Furthermore, Modern Aminos reserves the right to refuse sales to any individual or entity suspected of misusing its products.
If you have questions about the safe and lawful use of this product, consult a qualified professional with expertise in laboratory research. By proceeding with this purchase, you agree to these terms and conditions.
